MAOI

MAOI (monoamine oxidase inhibitor) is a type of antidepressant. This drug is able to relieve depression by working on neurotransmitters or a collection of chemicals in the brain that can convey signals between neurons / brain cells.

When someone is depressed, an enzyme called monoamine oxidase interferes with the removal of neurotransmitter substances consisting of norepinephrine, serotonin, and brain dopamine. MAOI works by blocking this process.

Besides being used to treat depression, MAOI is also sometimes prescribed by doctors to treat the symptoms of Parkinson's disease. MAOI is available in tablets and patches (transdermal).

warning:

• Women planning a pregnancy, who are pregnant or breastfeeding are advised to consult a doctor before taking MAOI. Based on the pregnancy category, this drug is included in category C, where animal studies show adverse effects on the fetus, but there are no controlled studies in pregnant women. The drug should only be used if the magnitude of the expected benefit exceeds the risk to the fetus.

• It is recommended not to drive or use heavy equipment when using MAOI drugs because it can cause drowsiness.
• Do not consume alcoholic beverages when using MAOI.
• This drug is thought to increase suicidal behavior or behavior in children and adolescents.
• Avoid consuming foods that contain tyramine, such as processed soybeans.
• Do not stop treatment without consulting a doctor first.
• Avoid taking other types of antidepressants, painkillers, colds and allergies, and herbal supplements when using MAOI, because it is feared that this drug will cause serotonin or other serious side effects.
• Some of the common side effects associated with using MAOI are dry mouth and nausea, skin reactions around the patched area, diarrhea, constipation and headaches.
• If an allergic reaction or overdose occurs after using MAOI, consult a doctor immediately.

For a more detailed explanation of the side effects, warnings, or interactions of each type of MAOI, please see Drugs A through Z.
Types and dosages of MAOI
Dosage of Drug Name
Adult isocarboxazide: 30 mg / day, in one or more doses. The maximum dose is 60 mg / day for 4 to 6 weeks.
Elderly: 5-10 mg / day.
Adult Phenelzine: 15 mg, can be increased up to four times after 2 weeks.
Elderly: 15 to 60 mg / day, divided into 3-4 doses.
Tranylcypromine Adult: 10-20 mg twice daily (morning and evening).
Selegilin (antiparkinson) Adult: 10 mg / day or 6 mg / day if given in transdermal form.

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