Resistance to leptin, one of the causes of fat accumulation becomes obese

Many people are wrong, say that fat people must eat too much and can not control themselves. In fact, cases of obesity are not so simple. In fact, there are other factors associated with obesity, namely the hormone leptin. Resistance to this hormone seems to be the main cause of fat accumulation in humans. How are you? Go, find out more about leptin resistance in the next review.
What is leptin?

Leptin is a hormone made by fat cells. His job is to control appetite and hunger. Leptin signals the brain to warn you when your stomach feels full.

In a part of the brain called the hypothalamus, there are receptors or special substances that receive signals from the hormone leptin which will be activated if the level of leptin in the body is too high.

If you are full, the hormone leptin will increase and then signal the receptor. The hypothalamus special receptor will receive a message that your stomach is full and reduces your appetite and hunger.

If leptin is a hormone that is too low in the body, it can cause overeating.
Leptin resistance is a disorder that can cause obesity

Fat people have a lot of fat in their fat cells. Because leptin is a hormone produced by fat cells, the amount of leptin present in the body is proportional to the amount of fat in the body. Therefore, fat people also have very high levels of leptin.

This level of leptin should prevent people from eating because your brain must know that your body already contains a lot of calories.

However, the problem is that the leptin signal is not functioning. There is a lot of leptin, but your brain can't detect it. This condition is called leptin resistance. Leptin becomes resistant and does not function properly because too much fat is entering. As a result, leptin levels are too high in the body.

Currently, leptin resistance is considered a major biological disorder in obese individuals.

When the brain does not receive leptin signals, your brain will think that your body is starving and need food, even if you have enough calories in the store.

This causes your brain to change your physiology and behavior to recover fats that are not thought of by your brain. Your brain mistakenly thinks that you have to eat so that you don't starve and tend to eat more. In addition, your brain also thinks that you need to save energy, which makes you more lazy and allows you to burn fewer calories at rest.

So, eating too much and not exercising causes overweight, but rather resistance to leptin.
What causes leptin resistance?

According to Dr. Guyenet, several cellular mechanisms of leptin resistance, among others.

Inflammation in parts of the hypothalamus brain can be a cause of resistance to leptin.
Having high levels of free fatty acids in the blood can increase fat metabolism in the brain and disrupt leptin signals.
Have high leptin levels.

Almost all of these factors increase in obese people. So, the two conditions are interconnected. Where people get bigger and leptin levels will get higher.
How to prevent leptin resistance?

The best way to find out if you have leptin resistance is to look in the mirror. If you have a lot of body fat, especially in the stomach area, then you almost certainly have leptin resistance.

To prevent leptin resistance, you can proceed in various ways:

Avoid processed foods because they can damage the intestines and trigger inflammation.
Consumption of soluble fiber can help improve intestinal health and fight obesity.
Enough exercise and physical activity.
Enough sleep.
Lower your triglycerides because triglyceride levels in the blood can prevent leptin transport from the blood and brain. The best way to reduce triglycerides is to reduce carbohydrate intake.
Eating lots of protein can cause weight loss.